Download this books into available format 2019 update. Susceptibility study of trypanosoma cruzi strains to benznidazole. Benznidazole tablets are the first fdaapproved treatment for chagas disease in children 2 to 12 years of age 1. Document complet derouler chapitre etendre sommaire version html imprimable. Pdf trypanosoma cruzi strains resistant to benznidazole occurring. Permiten al ser humano realizar determinados trabajos con mayor comodidad y menor esfuerzo. Benznidazole is a yellowish, practically crystalline powder that is practically insoluble in water, sparingly soluble in acetone and ethanol, and slightly soluble in methanol. Food and drug administration 10903 new hampshire avenue silver spring, md 20993 1888infofda 18884636332 contact fda. Benznidazole is an orally available, broad spectrum antimicrobial agent used in the treatment of chagas disease.
Benznidazole is an antibiotic that is used to treat chagas disease in children ages 2 through 12 years chagas disease also called american trypanosomiasis is an infection caused by a parasite common to the areas of south america, central america and mexico benznidazole was approved by the us food and drug administration fda on an accelerated basis. Juan rosasguzman, juan rosassaucedo, alma rosa jacqueline romerogarcia. Like other nitroimidazoles, benznidazole s main mechanism of action is to generate radical species which can damage the parasites dna or cellular machinery. It can be transmitted by eating food contaminated with the parasites feces or urine, blood transfusion from infected donors, organ transplant using. Benznidazole is a nitroimidazole similar to metronidazole and is associated with serum enzyme elevations during therapy in up to 10% of patients but has not linked to cases of clinically apparent acute liver injury. Benznidazole is an antiparasitic medication used in the treatment of chagas disease. Benznidazole is used to treat chagas disease american trypanosomiasis in children 2 to 12 years of age. The following license files are associated with this item. While it is highly effective in early disease this decreases in those who have longterm infection. Chagas disease is a potentially lifethreatening disease caused by the protozoan parasite, trypanosoma cruzi, also known as kissing bug. Estudiode laactividadtripanocidaydelosmecanismosdeaccionantiparasitaria. Benznidazole is a nitroimidazole antiparasitic with good activity against acute infection with trypanosoma cruzi, commonly referred to as chagas disease. It is the firstline treatment given its moderate side effects compared to nifurtimox. Benznidazole tablets are white round tablets each containing 12.
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